Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

If you want breakthrough science with tremendous growth opportunity, great colleagues and a stimulating work environment where you can make a difference in the lives of people with hearing disorders, we invite you to explore Decibel Therapeutics’ career opportunities.

To be considered for a position at Decibel Therapeutics, please submit your CV with the title of the position in the subject line to careers@decibeltx.com.

Equal Opportunity Employer M/F/D/V

Position Overview & Responsibilities:

As the Research Associate/Senior Research Associate, you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • BS or MS in pharmacology, biology, biochemistry, molecular and/or cellular biology
  • At least 5-10 years of relevant industry experience with in vitro cell-based or biochemical assays.
  • Demonstrated experience in plate based assays (fluorescence, luminescence, FRET, FP, high content imaging, label-free technologies, etc.)
  • Demonstrated experience in designing and developing physiological relevant cellular model systems for functional profiling of small molecule compounds and/or biologics.
  • Demonstrated experience with assay development and data analysis
  • Strong experimental background and bring a rigorous, analytical approach to problem solving
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team
  • Maintain accurate documentation of experiments
  • Highly effective written and verbal communication skills.

Knowledge, Skills, and Abilities:

  • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Familiarity with regenerative medicine strategies
  • Outstanding interpersonal and communication skills
  • Interact and communicate results and conclusions within the biology/pharmacology group
  • Review the scientific literature to remain abreast of developments in relevant fields

Position Overview and Responsibilities:
As the Senior Scientist, you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vivo and/or in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • PhD in pharmacology, neurobiology, molecular and/or cell biology with 3 to 5+ year’s relevant experience or BA or MA with 12 to 15+ year’s relevant industry experience
  • At least 5 years of experience working on early-stage and IND-enabling teams within the pharmaceutical industry
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, histology and RNA/protein expression techniques
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in other hearing-related fields (e.g. at least one of tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing)
  • Proven track record in new assay and high-through put assay development
  • Strong problem-solving skills
  • Ability to be productive in a fast-paced, team-work, multi-task environment
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team
  • Outstanding interpersonal and communication skills

Knowledge, Skills, and Abilities:

  • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Prepare protocols and SOPs for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology/pharmacology group and cross functional project teams
  • Review the scientific literature to remain abreast of developments in relevant fields

Preference will be given to candidates who additionally have:

  • Expertise in in vitro (cell lines and explants) models relevant to the inner ear with proven track record in assay development, implementation and execution
  • Detailed familiarity with cochlear anatomy and physiology, in vivo and/or in vitro models of inner ear function, inner ear imaging techniques, inner ear histopathology, electrophysiology
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear

The Position:
The Vice President of Biology will envision and lead the scientific team that will deliver high value targets for the company’s inner ear platform and therapeutic indications. You will have oversight for the development of the robust pipeline of molecular targets that ensures a steady stream therapeutics onwards. You will identify and maintain key external scientific relationships relevant to developing and maintaining the pipeline. By communicating accurately and regularly with team members, the Vice President will drive the strategy, progress, risks and risk mitigation plans for all Biology programs. As a key early hire for the company, a critical component of the job will be close collaboration with internal discovery teams and external investigators.

Requirements:

  • MD, PhD or MD PhD
  • Minimum of 15 years’ experience in industry, successfully leading teams towards drug discovery and/or 20 years’ experience in academia with an internationally acknowledged strong record of publications and mentoring
  • International reputation in the field of neurology or inner ear biology
  • Demonstrated leadership in a multi-discipline high performance team
  • Demonstrated ability to assess, prioritize, resource and shepherd programs forward
  • Outstanding interpersonal and communication skills

Preference will be given to candidates who additionally have:

  • Broad scientific expertise in the hearing field
  • Expertise in ototoxicity, growth factors, and/or cochlear implants
  • Outstanding oral and written presentation skills