Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

If you want breakthrough science with tremendous growth opportunity, great colleagues and a stimulating work environment where you can make a difference in the lives of people with hearing disorders, we invite you to explore Decibel Therapeutics’ career opportunities.

To be considered for a position at Decibel Therapeutics, please submit your CV with the title of the position in the subject line to

Equal Opportunity Employer M/F/D/V

Position Overview

We are seeking a motivated, skilled, and articulate Medical Director, Clinical Development, to play a key role in the development, conduct, and analysis of clinical programs in the field of hearing, including drugs to protect, repair, and restore hearing. The position will report to the Chief Medical Officer and will involve intense collaboration with academic investigators/ scientific experts to develop outstanding clinical protocols and ensure optimal study conduct, including development of data collection and study reporting systems and adherence to GCP guidelines and other relevant health authority regulations.


  • Responsible for developing and implementing the Development Strategy for assets assigned, including the design, conduct, and interpretation of data from Phase 1 and 1/2 studies, and pediatric studies as required to fulfill regulatory requirements.
  • Provide clinical development input to pre-clinical programs approaching IND-enabling tox.
  • Bring programs into the clinic.
  • Direct all aspects of activities relating to: preparation of protocols, clinical trials, data analyses, and written study reports, including being the medical monitor for clinical trials.
  • Develop strong network of clinical advisors to provide input on Decibel’s clinical development programs and to serve as investigators on studies.
  • Lead study teams to ensure that the clinical aspects of protocols are properly executed.
  • Interact with CRO and other vendor relationships.
  • Serve as primary interface with internal stakeholders as well as external thought leaders and regulatory authorities for assigned programs.
  • As business needs require, provide technical evaluation of business development activities for proof of concept stage hearing assets.


  • At least 3 years in pharmaceutical industry with experience in leading clinical trials supporting registration and interaction with global regulatory authorities.
  • Professional credentials as a physician (MD).
  • Experience in audiology, otolaryngology, or neurology preferred.
  • Experience in running gene therapy trials is a plus.
  • Experience in leading and managing project teams and managing multiple projects concurrently.
  • Thorough knowledge of clinical trial approval processes, including a strong grasp of international guidelines and regulations (FDA, ICH, and GCP).

Additional Desirable Experience

  • Excellent oral and written communication skills as well as the ability to facilitate analysis and problem solving through the effective facilitation of group activities.
  • Strong organizational and time management skills, including the ability to function effectively in a team environment.
  • Demonstrated professionalism and adherence to high ethical standards.
  • Demonstrated ability to manage multiple priorities to achieve results and meet milestones in a “hands-on” fashion.

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law. All employment is decided on the basis of qualifications, merit, and business need.

The Senior/Principal Computational Scientist, reporting to the Director of Computational Biology, will work as part of cross-functional project teams to drive research focused on the elucidation of hearing biology and the discovery and development of therapeutics for hearing loss.  Responsibilities will include:

  • Help develop a robust platform for genomics-based target discovery, including single-cell RNAseq data, population genetic data, and genetic screen data.
  • Apply and/or develop data-mining techniques for target identification and validation.
  • Apply machine learning and statistical approaches to establish and benchmark predictive models of biological data.
  • Help guide design of gene therapies, including computational aspects of promoter and capsid optimization.
  • Enhance the scientific reputation of the company through publishing and/or or presenting technical papers to internal and external audiences, and/or contributing to patent applications.
  • Design and develop innovative, robust, analysis pipelines that can be applied in a research and clinical setting.
  • Develop and contribute to external collaborations and partnerships.


  • M.S./Ph.D. in bioinformatics, computational biology, genetics or a related discipline.
  • Strong understanding of cellular and molecular biology. Understanding of hearing biology is a plus.
  • Expertise in computational biology, genomics and other high throughput data platforms including scRNAseq. Aptitude to apply experimental methods to understand disease biology and drug discovery.
  • Proficiency in programming and computational analysis. Experience with R, Python and SQL are desirable.
  • Ability to apply and develop tools for integrative analysis and visualization of multi-dimensional datasets, integrating biochemical, cellular and genomic data using appropriate statistical methods to drive drug discovery projects.
  • Ability to work effectively with internal and external collaborators to funnel emerging genomics discoveries to guide internal programs and identify partners/consultants to complement internal bioinformatics efforts.
  • Other ideal areas of scientific expertise:
    • Fundamental statistics and machine learning applications to life sciences
    • Predictive modeling, benchmarking
    • Experience with mining public data sets
  • Technical proficiencies should include:
    • Linux in a grid or cloud environment.
    • One or more scripting and statistical languages
    • Distributed computing
  • Excellent written and verbal communication skills, particularly of complex information and concepts.


Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.