Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

If you want breakthrough science with tremendous growth opportunity, great colleagues and a stimulating work environment where you can make a difference in the lives of people with hearing disorders, we invite you to explore Decibel Therapeutics’ career opportunities.

To be considered for a position at Decibel Therapeutics, please submit your CV with the title of the position in the subject line to careers@decibeltx.com.

Equal Opportunity Employer M/F/D/V

Position Overview & Responsibilities:

Decibel Therapeutics is looking for a Research Associate/Scientist with experience in in vivo electrophysiology to be part of the pharmacology team working to test potential novel therapies for hearing loss. The primary responsibilities are to help develop and to execute studies requiring functional assays (auditory brainstem response; otoacoustic emissions) for quantitating hearing status/hearing loss in animal models. The individual in this position will have the opportunity to work closely with biology and drug delivery/PK teams, across multiple projects and indications.

The successful candidate will be highly motivated to work as part of a team in a fast-paced, dynamic environment. Additionally, the ideal candidate will be highly self-motivated and enthusiastic to join the wider Decibel team in working to understand the bases of hearing losses and to generate treatments that benefits patients, their families and communities.

Requirements

  • BS, MS or PhD in Neuroscience, Physiology, Pharmacology, Biology, or related fields
  • 0-2 years with PhD/ 2 years with MS of research experience in industry or academic laboratories
  • Hands-on experience with in vivo electrophysiology (field potentials, multi-unit, or single-unit), including data acquisition, analysis, and visualization
  • Excellent animal handling and experience with IP, IV, PO administration
  • Ability to develop and execute research studies, critically assess data quality and results, and effectively communicate results to the team
  • High level of interpersonal skills, including working/communicating with multiple teams
  • Ability to time-manage and work on multiple projects
  • Ability to work in a dynamic environment

Additional desirable experience

  • Developing animal models, especially animal models of hearing loss
  • Recording auditory brainstem response, otoacoustic emissions, or other auditory evoked responses
  • Surgery and dissection

Position Overview and Responsibilities:
As a Scientist, Hearing Biology you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vivo and/or in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • PhD in neurobiology, molecular and/or cell biology with 1 to 3+ years’ relevant experience or BA or MA with  to 3-6+ years’ relevant industry experience
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, surgical approaches for delivery to the inner ear, AAV gene delivery, dissection and histology of the adult inner ear, microscopy, and RNA/protein analysis
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in other hearing-related fields (e.g. at least one of tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing)
  • Strong problem-solving skills
  • Ability to be productive in a fast-paced, team-work, multi-task environment
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team
  • Outstanding interpersonal and communication skills

Knowledge, Skills, and Abilities:

  • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Prepare protocols and SOPs for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology/pharmacology group and cross functional project teams
  • Review the scientific literature to remain abreast of developments in relevant fields

Preference will be given to candidates who additionally have:

  • Expertise in in vitro (cell lines and explants) models relevant to the inner ear with proven track record in assay development, implementation and execution
  • Detailed familiarity with cochlear anatomy and physiology, in vivo and/or in vitro models of inner ear function, AAV delivery to the inner ear, inner ear imaging techniques, microdissection of the adult inner ear, inner ear histopathology, electrophysiology

Position Overview & Responsibilities:

As a member of the quantitative ADME sciences group, you will be responsible for providing in-vitro ADME, in vivo pharmacokinetic (PK), and PK/PD guidance to Decibel’s project teams. The primary focus of this individual will be helping to build Decibel’s drug discovery pipeline. However, responsibilities of this position will expand as Decibel’s programs progress into clinical development. As one of the key early hires for the company, you will have the opportunity to establish and grow industry leading ADME/PK support capabilities (through external CROs or internally via platform building) that are applicable to the inner ear. This person will be a key functional leader and stakeholder to ensure we achieve our goal of developing a strong pipeline of breakthrough drugs to protect, repair and restore hearing. This is an excellent opportunity for a driven individual looking for a broad-based experience in a fast-paced, dynamic, biotech start-up environment.

 

Specifically, the candidate will:

  • Help drive programs forward by being a drug disposition subject matter expert on project teams
  • Manage external drug disposition efforts at contract research organizations including ADME/PK studies and regulated bioanalysis (nonclinical TK and clinical PK)
  • Develop ADME/PK/BioA infrastructure to meet near-term and long-term vision and enhance our understanding of inner ear disposition
  • In collaboration with pharmacology colleagues, conduct PK/PD analysis to establish exposure/response relationships
  • In collaboration with non-clinical safety/toxicology, conduct TK analysis to establish exposure/toxicity relationships
  • Employ allometric scaling and PK translation principles to predict human PK from pre-clinical animal species; help guide dosing strategy in FIH studies and estimate TI
  • Write relevant pharmacokinetic sections of regulatory filings (IND/CTA, NDA/MAA)
  • Establish and implement quantitative ADME sciences standard operating procedures and work cross functionally to build a cohesive SOP infrastructure
  • Work cross functionally to build data archiving/visualization capabilities that are scalable with organizational growth
  • Manage internal full-time or contract drug disposition scientists

 

Requirements:

  • PhD with 8+ years of experience in drug disposition/DMPK. Candidates with MS or BA/BS could be considered based on experience and qualifications
  • Experience/expertise in small molecule bioanalysis required. Experience in large molecule (peptide, protein) experience is a plus
  • Use of industry standard PK analysis software (WinNonlin) is required. Experience with other PK analysis platforms (eg nonmem) and/or PB/PK platforms (eg simcyp) is a plus
  • Ability to work in a collaborative fashion with many different disciplines both internally and with external collaborators
  • Must be a team player with a proven track record of success in highly matrixed work environments
  • Ability to multi-task and prioritize to manage multiple projects simultaneously
  • Must have excellent oral and written communication/presentation skills

Position Overview and Responsibilities:
As the Senior Scientist, you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vivo and/or in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • PhD in pharmacology, neurobiology, molecular and/or cell biology with 3 to 5+ year’s relevant experience or BA or MA with 12 to 15+ year’s relevant industry experience
  • At least 5 years of experience working on early-stage and IND-enabling teams within the pharmaceutical industry
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, histology and RNA/protein expression techniques
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in other hearing-related fields (e.g. at least one of tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing)
  • Proven track record in new assay and high-through put assay development
  • Strong problem-solving skills
  • Ability to be productive in a fast-paced, team-work, multi-task environment
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team
  • Outstanding interpersonal and communication skills

Knowledge, Skills, and Abilities:

  • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Prepare protocols and SOPs for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology/pharmacology group and cross functional project teams
  • Review the scientific literature to remain abreast of developments in relevant fields

Preference will be given to candidates who additionally have:

  • Expertise in in vitro (cell lines and explants) models relevant to the inner ear with proven track record in assay development, implementation and execution
  • Detailed familiarity with cochlear anatomy and physiology, in vivo and/or in vitro models of inner ear function, inner ear imaging techniques, inner ear histopathology, electrophysiology
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear