Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

If you want breakthrough science with tremendous growth opportunity, great colleagues and a stimulating work environment where you can make a difference in the lives of people with hearing disorders, we invite you to explore Decibel Therapeutics’ career opportunities.

To be considered for a position at Decibel Therapeutics, please submit your CV with the title of the position in the subject line to careers@decibeltx.com.
Equal Opportunity Employer M/F/D/V

Associate Director Pharmacology

Responsibilities:

As an Associate Director, you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vivo and/or in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform and lead one of the Decibel’s drug discovery programs. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • PhD in pharmacology, neurobiology, molecular and/or cell biology with 3 to 5+ year’s relevant experience or Bachelors or Master’s degree with 12 to 15+ year’s relevant industry experience
  • At least 5 years of experience working on early-stage and IND-enabling teams within the pharmaceutical industry
  • Experience in evaluating, establishing and managing successful drug discovery projects with a proven track record in characterizing and moving compounds into clinical development
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, histology and RNA/protein expression techniques
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in other hearing-related fields (e.g. at least one of tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing)
  • Proven track record in new assay and high-through put assay development
  • Strong problem-solving skills
  • Ability to be productive in a fast-paced, team-work, multi-task environment
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team
  • Outstanding interpersonal and communication skills
  • Strong track record in mentoring, leading and developing junior scientists

Knowledge, Skills, and Abilities:

Preference will be given to candidates who additionally have:

  • Expertise in in vitro (cell lines and explants) and in vivo models relevant to the inner ear with proven track record in assay development, implementation and execution
  • Detailed familiarity with cochlear anatomy and physiology, in vivo and/or in vitro models of inner ear function, inner ear imaging techniques, inner ear histopathology, electrophysiology
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear

 

The Company
Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

Position Overview & Responsibilities:

As the Director of Business Development, you will report to the EVP Corporate Development and drive Decibel’s business development activities, as well as support strategy, new product planning, and public relations functions. This is an excellent opportunity for a driven individual looking for a broad-based experience in a fast-paced, dynamic, biotech start-up environment. This versatile and highly motivated individual will wear many hats and will have the capacity to drive numerous projects forward simultaneously. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that emerging options for our programs are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate-aligned goals.

Specifically, s/he will:

• Source and screen potential licensing opportunities, coordinating due diligence, term sheets, negotiation, contracting, and decision-making.
• Contribute to and execute a comprehensive non-dilutive revenue strategy for Decibel, including industry partnerships, government grants, lobbying, and outreach to foundations and patient advocacy groups.
• Support partnering activities, including preparing pitch decks, term sheets, and other materials as needed to support negotiations and diligence activities.
• Provide analytic support by conducting product/market forecasts, NPV valuations, and other financial analyses as needed in support of R&D and corporate business decisions.
• Coordinate Decibel scientists, legal and administrative staff, and external legal firms to manage workflow in delivering academic/industry collaborations (SRAs, MTAs, CDAs, etc.).
• In conjunction with IP/legal/finance leadership at Decibel, manage fulfillment of contractual obligations, including reporting, payments, and compliance.
• Manage non-standard contracts including with scientific/medical advisors, and other vendors.

Requirements:

• BA/BS required; MBA plus graduate degree in scientific / medical discipline (Ph.D. or M.D.) strongly preferred.
• 5+ years biopharmaceutical experience; candidates with industry, as well as relevant investment banking and consulting backgrounds, will be considered.
• High energy individual with a positive “nothing is impossible” attitude.
• Ability to work in a hands-on collaborative fashion with many different disciplines both inside and outside of the company.
• Strong knowledge of biotechnology industry, drug discovery and development process.
• Ability to work independently in an entrepreneurial, matrixed environment.
• Ability to multi-task and prioritize to manage multiple projects simultaneously.
• Ability to perform complex financial calculations such as NPV and product forecasting.
• Experience with commercial and scientific assessment of new product opportunities.
• Excellent oral and written (Word, PPT) communication/presentation skills for internal and external audiences.

The Company

Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

Position Overview and Responsibilities:
The Director, Corporate Development is a general athlete role reporting to the EVP, Corporate Development, with core responsibilities spanning commercial assessment, and corporate strategy and planning, and with assignments flexing into business development, and program leadership & management.

• Lead commercial assessments
o Develop commercial disease strategies for core therapeutic indications
o Develop commercial strategies for pipeline assets to inform target product profiles and development milestone decisions
o Lead commercial assessments on business development opportunities

• Partner with EVP Corporate Development to lead corporate strategy and planning processes
o Annual refresh on 5-year plan
o Annual corporate goal setting and quarterly corporate goal tracking
o Work with finance and organization to ensure budget reflects corporate and program strategy
o Corporate communications strategy
o Staff role for Executive Leadership Team (ELT) meetings

• Support business development and financing efforts as needed,
o Financial modeling
o Project team management

The successful candidate has:
• 10+ years’ experience in biopharma companies and related fields, across an eclectic range of roles
• Masters or PhD in science, plus MBA or consulting experience desirable
• A passion for developing and delivering hearing therapeutics
• Hopeless intellectual curiosity and a drive to make things work better
• Ability to work independently in an entrepreneurial, matrixed environment.
• Ability to multi-task and prioritize to manage multiple projects simultaneously.
• Strong interpersonal, communication, and organizational skills, and facility for contributing to and leading matrixed and cross-functional project teams
• Business development experience a plus

The Company

Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

Position Overview & Responsibilities:

As a Clinical Research Scientist, reporting to the Senior Director, New Product Planning, and working as an integral member of the Clinical Center of Excellence, you will lead the development and execution of audiometric data analysis, contribute to clinical study designs, and conduct internal clinical research projects. You will also be intimately involved in building a clinical data analysis and management program within Decibel. This role requires expertise in biomedical signal processing and analysis, software programming, and research (preferably clinical).
Key responsibilities include:
• Lead development and implementation of data analytic approaches for clinical audiometric data
o Approaches include multi-variate statistics, signal processing, parameter estimation
o Includes software programming, potentially across multiple hardware platforms and/ or programming languages
o May include development of software for novel audiometric testing protocols
• In collaboration with the Information Technology & Data Sciences team
o Build a well-documented, scalable and flexible approach to internal audiometric data analysis and data management
o Assure and maintain quality of Decibel internal audiometric databases
o Support external collaborations and databases with data analysis expertise
• Participate in the conduct of in-house clinical studies with human research participants. Activities will include experimental design, collection, and analysis of behavioral and physiologic data
• Communicate and report findings internally; contribute and/ or lead work on external research papers

Requirements & experience:
• Advanced degree (Ph.D, or M.S. with 2-3 years additional relevant experience) in one of the following (or similar) fields: hearing science, biomedical engineering, neuroscience, physics, statistics, experimental psychology

• Demonstrated experience in biomedical data analysis and signal processing; track record of developing innovative approaches to problem solving
• Demonstrated experience in a field of experimental research
• Programming experience in several languages (e.g. relevant ones include MatLab, R, Python, C++, Java, etc.)
• Ability to structure ambiguous problems; develop practical approaches to conceptual situations
• Ability to outperform as a team member and lead development of a collaborative culture
• Appetite for working in a highly matrixed style in a small, dynamic company
• Ability to grasp complex domains and communicate key messages clearly in verbal and written form
Preference will be given to candidates who additionally have:

• Expertise in sound and/ or hearing (acoustics, auditory perception or physiology; hearing assistive devices)
• Knowledge of speech production and understanding
• Experience conducting research with human subjects

Director/Senior Director, DMPK

The Position 

Decibel is seeking a Senior Director, DMPK, reporting to the CSO, the qualified candidate will be responsible for:

  • Providing DMPK expertise as a project representative on multi-disciplinary drug discovery and development teams
  • Guiding discovery project teams for candidate selection, developing and driving DMPK strategies for lead optimization and solving ADME issue, designing in vitro and in vivo DMPK studies and interpreting results
  • The application of modeling approaches (in silico, PK, PBPK) to support human pharmacokinetics and dose predictions and quantitative risk assessment of drug-drug interactions, conducting PK/PD modeling, monitoring of GLP bioanalysis, and CRO management
  • As compounds progress into clinical development, this person may be responsible for the clinical pharmacokinetic aspect of clinical trials.
  • The candidate will be required to generate, analyze and present data, both orally and as written reports
  • Authoring and/or reviewing various regulatory documents

Qualifications

  • PhD in Pharmacokinetics, Pharmaceutical Sciences, or related field with a specific focus on pharmacokinetics with a minimum of 12 years of relevant industry experience is required
  • Previous people management experience is required
  • Proven track record of supporting drug discovery and development as DMPK project representative on multifunctional project teams is required
  • Extensive understanding of DMPK principles is required
  • Previous experience with IND, a plus
  • Proven skills in pharmacokinetic modeling, including application of SimCyp and/or Gastroplus PBPK, Phoenix WinNonlin, and/or NONMEM are preferred
  • Knowledge of GLP, development and regulatory guidelines is required
  • Monitoring of DMPK studies at CRO is preferred
  • The ability to work independently, excellent interpersonal, organizational, oral/written communication and teamwork skills, ability to multi task and prioritize to delivery results within tight timelines are required

Position Overview & Responsibilities:

As the Senior Research Associate, you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vivo and/or in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • BS or MS in pharmacology, biology, molecular and/or cellular biology
  • At least 3 to 5 years of hands-on experience with in vivo models, cell culture,

RT-PCR, Elisa, protein analysis, DNA prep

  • Demonstrated ability to thrive in a team environment
  • Strong experimental background and bring a rigorous, analytical approach to problem solving
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team

Knowledge, Skills, and Abilities:

  • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Prepare protocols and SOPs for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology/pharmacology group and cross functional project teams
  • Review the scientific literature to remain abreast of developments in relevant fields

Preference will be given to candidates who additionally have:

  • Expertise in in vitro (cell lines and explants) models relevant to the inner ear with proven track record in assay development, implementation and execution
  • Familiarity with cochlear anatomy and physiology, in vivo and/or in vitro models of inner ear function, inner ear imaging techniques, inner ear histopathology, electrophysiology
  • Familiarity with regenerative medicine strategies, preferably in the inner ear
  • Demonstrated experience with assay development
  • Facile vocabulary re inner ear imaging techniques, inner ear histopathology, cochlear function, models of cochlear dysfunction
  • Familiarity with inner ear anatomy and function
  • Ability to be productive in a fast-paced, team-work, multi-task environment
  • Outstanding interpersonal and communication skills

Position Overview and Responsibilities:

As the Senior Scientist, you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vivo and/or in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • PhD in pharmacology, neurobiology, molecular and/or cell biology with 3 to 5+ year’s relevant experience or BA or MA with 12 to 15+ year’s relevant industry experience
  • At least 5 years of experience working on early-stage and IND-enabling teams within the pharmaceutical industry
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, histology and RNA/protein expression techniques
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in other hearing-related fields (e.g. at least one of tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing)
  • Proven track record in new assay and high-through put assay development
  • Strong problem-solving skills
  • Ability to be productive in a fast-paced, team-work, multi-task environment
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team
  • Outstanding interpersonal and communication skills

Knowledge, Skills, and Abilities:

  • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Prepare protocols and SOPs for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology/pharmacology group and cross functional project teams
  • Review the scientific literature to remain abreast of developments in relevant fields

Preference will be given to candidates who additionally have:

  • Expertise in in vitro (cell lines and explants) models relevant to the inner ear with proven track record in assay development, implementation and execution
  • Detailed familiarity with cochlear anatomy and physiology, in vivo and/or in vitro models of inner ear function, inner ear imaging techniques, inner ear histopathology, electrophysiology
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear

The Position

The Vice President of Biology will envision and lead the scientific team that will deliver high value targets for the company’s inner ear platform and therapeutic indications. You will have oversight for the development of the robust pipeline of molecular targets that ensures a steady stream therapeutics onwards. You will identify and maintain key external scientific relationships relevant to developing and maintaining the pipeline. By communicating accurately and regularly with team members, the Vice President will drive the strategy, progress, risks and risk mitigation plans for all Biology programs. As a key early hire for the company, a critical component of the job will be close collaboration with internal discovery teams and external investigators.

Requirements:

  • MD, PhD or MD PhD
  • Minimum of 15 years’ experience in industry, successfully leading teams towards drug discovery and/or 20 years’ experience in academia with an internationally acknowledged strong record of publications and mentoring
  • International reputation in the field of neurology or inner ear biology
  • Demonstrated leadership in a multi-discipline high performance team
  • Demonstrated ability to assess, prioritize, resource and shepherd programs forward
  • Outstanding interpersonal and communication skills

Preference will be given to candidates who additionally have:

  • Broad scientific expertise in the hearing field
  • Expertise in ototoxicity, growth factors, and/or cochlear implants
  • Outstanding oral and written presentation skills