Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

If you want breakthrough science with tremendous growth opportunity, great colleagues and a stimulating work environment where you can make a difference in the lives of people with hearing disorders, we invite you to explore Decibel Therapeutics’ career opportunities.

To be considered for a position at Decibel Therapeutics, please submit your CV with the title of the position in the subject line to careers@decibeltx.com.

Equal Opportunity Employer M/F/D/V

Position Overview & Responsibilities:

The Informatics Associate provides technical and business workflow analysis and end user support for scientific applications used in areas across Preclinical Research, Clinical Development and G&A functions to support the company daily operating needs and future growth.

In this role the successful candidate will communicate with scientific application users and leaders to understand their needs and challenges and requirements for software systems. The Informatics Associate will take direct action to respond to needs, troubleshoot problems, and facilitate productivity through utilization of application resources. Responsibilities also include developing business processes and workflows for data management systems, tracking, acquisition, and analysis of data based upon the needs of internal research customers. The role calls for a combination of scientific training and informatics expertise. A strong technical background in Life Science applications, coupled with exceptional customer service skills is needed.

  • Support end-user applications to help with application functionality, future configurations and troubleshoot basic problems; Learn internal systems to become the knowledge expert.
  • Develop scripts, workflows, and automation procedures for routine lab workflows
  • Handle escalated technical issues both with IT and Informatics related issues/requests for applications used within the company
  • Assist in managing interactions with support resources from software vendors or external help desk(s)
  • Collaborate with cross functional groups of experts in other parts of the IT organization as required
  • Assist with testing of new system deployments, UAT scripts, and documentation of systems or workflows.
  • Work closely with external MSP for HelpDesk items and resolution of higher priority issues pertaining to deployed applications
  • Conduct or organize systems/platform trainings for new applications or updates to platforms/applications
  • Conduct and/or coordinate system updates across the company.  Schedule/Deliver corporate applications trainings.

Requirements:

The qualified candidate will possess a track record of providing software implementation and support services in a life science or healthcare environment. Technical acumen, excellent written and verbal communication skills, and a demonstrated potential to continually grow into new responsibilities are needed. They must be self-motivated and able to work independently, but also recognize when to reach for assistance from other available resources to solve problems. Specific qualifications include:

  • BA/BS/MS in Computer Science, Engineering or related technical disciplines preferred
  • 3-7+ years of relevant professional experience in academic or biopharma research institution
  • Training in a relevant life science
  • Expert user experience with several scientific applications for biology, chemistry, or pharmacology such as LIMS, SDMS, Data Visualization, ELN’s and others.(Biovia, IDBS, ChemAxon, Dotmatics, related)
  • Familiarity with clinical systems such as EDC, eTMF, CTMS and others would be beneficial but not required
  • Familiarity with scientific software used for computation and visualization.
  • Ability to create automation scripts using shell scripting, Python, SQL, and related scripting and query languages, experience with tools such as Pipeline Pilot, Spotfire, Tableau is a plus
  • Experience supporting researchers and scientists in biotech/pharma, or equivalent academic research computing environment.
  • Exceptional analytical, problem-solving, and troubleshooting abilities.
  • Strong written and verbal communication skills.

 

As a Scientist, Hearing Biology you will be expected to work equally well as a self-starter and as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vivo and/or in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • PhD in neurobiology, molecular and/or cell biology with 1 to 3+ years’ relevant experience or BA or MA with 3 to 6+ years’ relevant industry experience
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, surgical approaches for delivery to the inner ear, AAV gene delivery, dissection and histology of the adult inner ear, microscopy, and RNA/protein analysis
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in other hearing-related fields (e.g. at least one of tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing)
  • Strong problem-solving skills
  • Ability to be productive in a fast-paced, team-work, multi-task environment
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team
  • Outstanding interpersonal and communication skills

Knowledge, Skills, and Abilities:

  • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Prepare protocols and SOPs for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology/pharmacology group and cross functional project teams
  • Review the scientific literature to remain abreast of developments in relevant fields

Preference will be given to candidates who additionally have:

  • Expertise in in vitro (cell lines and explants) models relevant to the inner ear with proven track record in assay development, implementation and execution
  • Detailed familiarity with cochlear anatomy and physiology, in vivo and/or in vitro models of inner ear function, AAV delivery to the inner ear, inner ear imaging techniques, microdissection of the adult inner ear, inner ear histopathology, electrophysiology

Decibel Therapeutics is looking for a Scientist with experience in the auditory system to be part of the pharmacology team working to identify novel therapies for the treatment of hearing loss.

As a Scientist, you will be expected to work equally well as a self-starter and as a member of a matrixed team within Decibel. Your focus will be to develop and execute appropriate in vivo assays required for the advancement of specific high priority projects as well as Decibel’s inner ear platform. You will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and are grounded in realistic, corporate aligned goals.

In this position you will lead the design and execution of in vivo pharmacology studies to determine the efficacy profile of novel compounds and their potential to treat hearing loss, using a variety of assays. In addition, you will be responsible for data analysis and interpretation and formulating the path for advancement through Decibel’s discovery programs.

The individual in this position will have the opportunity to work closely with biology, drug delivery/PK and translational research teams, across multiple projects and indications.

The successful candidate will be highly motivated to work as part of a team in a fast-paced, dynamic environment. Additionally, the ideal candidate will be highly enthusiastic to join the wider Decibel team in working to understand the bases of hearing losses and to generate treatments that benefits patients, their families and communities.

Requirements

  • PhD in pharmacology, molecular and/or cell biology or neurobiology with 3 to 5+ years relevant experience or Bachelors or Master’s degree with 12 to 15+ year’s relevant industry experience
  • Hands-on experience with in vivo electrophysiology (field potentials, multi-unit, or single-unit), including data acquisition, analysis, and visualization
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, molecular and cell biology, cell signaling and RNA/protein expression techniques
  • Experience in designing and executing experimental strategies to validate and understand the mechanism of action for identified targets
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in hearing-related fields (e.g. at least one of: tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing) or other indications
  • Ability to develop and execute research studies, critically assess data quality and results, and effectively communicate results to the team
  • Strong problem-solving skills
  • High level of interpersonal skills, including working/communicating with multiple teams
  • Ability to time-manage and work on multiple projects
  • Ability to work in a dynamic environment

The Senior Computational Scientist, reporting to the Director of Computational Biology, will work as part of cross-functional project teams to drive research focused on the elucidation of hearing biology and the discovery and development of therapeutics for hearing loss.  Responsibilities will include:

  • Help develop a robust platform for genomics-based target discovery, including single-cell RNAseq data, population genetic data, and genetic screen data.
  • Apply and/or develop data-mining techniques for target identification and validation.
  • Apply machine learning and statistical approaches to establish and benchmark predictive models of biological data.
  • Help guide design of gene therapies, including computational aspects of promoter and capsid optimization.
  • Enhance the scientific reputation of the company through publishing and/or or presenting technical papers to internal and external audiences, and/or contributing to patent applications.
  • Design and develop innovative, robust, analysis pipelines that can be applied in a research and clinical setting.
  • Develop and contribute to external collaborations and partnerships.

Requirements:

  • M.S./Ph.D. in bioinformatics, computational biology, genetics or a related discipline.
  • Strong understanding of cellular and molecular biology. Understanding of hearing biology is a plus.
  • Expertise in computational biology, genomics and other high throughput data platforms including scRNAseq. Aptitude to apply experimental methods to understand disease biology and drug discovery.
  • Proficiency in programming and computational analysis. Experience with R, Python and SQL are desirable.
  • Ability to apply and develop tools for integrative analysis and visualization of multi-dimensional datasets, integrating biochemical, cellular and genomic data using appropriate statistical methods to drive drug discovery projects.
  • Ability to work effectively with internal and external collaborators to funnel emerging genomics discoveries to guide internal programs and identify partners/consultants to complement internal bioinformatics efforts.
  • Other ideal areas of scientific expertise:
    • Fundamental statistics and machine learning applications to life sciences
    • Predictive modeling, benchmarking
    • Experience with mining public data sets
  • Technical proficiencies should include:
    • Linux in a grid or cloud environment.
    • One or more scripting and statistical languages
    • Distributed computing
  • Excellent written and verbal communication skills, particularly of complex information and concepts.

Decibel is seeking a Human Genetics Scientist, reporting to the Director of Computational Biology, to help drive collection and analysis of data around the genetics of hearing function, hearing loss, and genetic deafness. Responsibilities will include:

  • Design, conduct, and analyze human genetics studies to help drive drug discovery and development.
    • Identify and develop relationships with appropriate external partners.
    • Develop sample collection and genotyping strategy.
    • Work with translational sciences group to develop cohort selection and phenotyping strategies.
    • Develop and implement computational analysis strategy with appropriate statistical rigor.
  • Help develop a robust platform for human genetics data storage and access.
  • Help guide genomics platform efforts at Decibel, including genetic screening, single-cell RNAseq, and other data types.
  • Apply and/or develop data-mining techniques for target identification.
  • Apply machine learning and statistical approaches to establish and benchmark predictive models of disease.
  • Enhance the scientific reputation of the company through publishing and/or or presenting technical papers to internal and external audiences, and/or contributing to patent applications.
  • Design and develop innovative, robust analysis pipelines that can be applied in a research and clinical setting.
  • Develop and contribute to external collaborations and partnerships.

Requirements:

  • M.S./Ph.D. in bioinformatics, computational biology, genetics or a related discipline.
  • Strong understanding of statistical and population genetics. Understanding of hearing biology is a plus.
  • Experience in human genetic analysis and its application to practical problems.
  • Proficiency in programming and computational analysis. Experience with R, Python and SQL are desirable.
  • Ability to apply and develop tools for integrative analysis and visualization of multi-dimensional datasets, integrating biochemical, cellular and genomic data using appropriate statistical methods to drive drug discovery projects.
  • Ability to work effectively with internal and external collaborators to funnel emerging genomics discoveries to guide internal programs and identify partners/consultants to complement internal bioinformatics efforts.
  • Other ideal areas of scientific expertise:
    • Fundamental statistics and machine learning applications to life sciences
    • Predictive modeling, benchmarking
    • Experience with mining public data sets
  • Technical proficiencies should include:
    • Linux in a grid or cloud environment.
    • One or more scripting and statistical languages
    • Distributed computing
  • Excellent written and verbal communication skills, particularly of complex information and concepts.

As a member of the quantitative ADME sciences group, you will be responsible for providing in-vitro ADME, in vivo pharmacokinetic (PK), and PK/PD guidance to Decibel’s project teams. The primary focus of this individual will be helping to build Decibel’s drug discovery pipeline. However, responsibilities of this position will expand as Decibel’s programs progress into clinical development. As one of the key early hires for the company, you will have the opportunity to establish and grow industry leading ADME/PK support capabilities (through external CROs or internally via platform building) that are applicable to the inner ear. This person will be a key functional leader and stakeholder to ensure we achieve our goal of developing a strong pipeline of breakthrough drugs to protect, repair and restore hearing. This is an excellent opportunity for a driven individual looking for a broad-based experience in a fast-paced, dynamic, biotech start-up environment.

 

Specifically, the candidate will:

  • Help drive programs forward by being a drug disposition subject matter expert on project teams
  • Manage external drug disposition efforts at contract research organizations including ADME/PK studies and regulated bioanalysis (nonclinical TK and clinical PK)
  • Develop ADME/PK/BioA infrastructure to meet near-term and long-term vision and enhance our understanding of inner ear disposition
  • In collaboration with pharmacology colleagues, conduct PK/PD analysis to establish exposure/response relationships
  • In collaboration with non-clinical safety/toxicology, conduct TK analysis to establish exposure/toxicity relationships
  • Employ allometric scaling and PK translation principles to predict human PK from pre-clinical animal species; help guide dosing strategy in FIH studies and estimate TI
  • Write relevant pharmacokinetic sections of regulatory filings (IND/CTA, NDA/MAA)
  • Establish and implement quantitative ADME sciences standard operating procedures and work cross functionally to build a cohesive SOP infrastructure
  • Work cross functionally to build data archiving/visualization capabilities that are scalable with organizational growth
  • Manage internal full-time or contract drug disposition scientists

 

Requirements:

  • PhD with 8+ years of experience in drug disposition/DMPK. Candidates with MS or BA/BS could be considered based on experience and qualifications
  • Experience/expertise in small molecule bioanalysis required. Experience in large molecule (peptide, protein) experience is a plus
  • Use of industry standard PK analysis software (WinNonlin) is required. Experience with other PK analysis platforms (eg nonmem) and/or PB/PK platforms (eg simcyp) is a plus
  • Ability to work in a collaborative fashion with many different disciplines both internally and with external collaborators
  • Must be a team player with a proven track record of success in highly matrixed work environments
  • Ability to multi-task and prioritize to manage multiple projects simultaneously
  • Must have excellent oral and written communication/presentation skills

As the Senior Scientist, you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vivo and/or in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • PhD in pharmacology, neurobiology, molecular and/or cell biology with 3 to 5+ year’s relevant experience or BA or MA with 12 to 15+ year’s relevant industry experience
  • At least 5 years of experience working on early-stage and IND-enabling teams within the pharmaceutical industry
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, histology and RNA/protein expression techniques
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in other hearing-related fields (e.g. at least one of tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing)
  • Proven track record in new assay and high-through put assay development
  • Strong problem-solving skills
  • Ability to be productive in a fast-paced, team-work, multi-task environment
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team
  • Outstanding interpersonal and communication skills

Knowledge, Skills, and Abilities:

  • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Prepare protocols and SOPs for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology/pharmacology group and cross functional project teams
  • Review the scientific literature to remain abreast of developments in relevant fields

Preference will be given to candidates who additionally have:

  • Expertise in in vitro (cell lines and explants) models relevant to the inner ear with proven track record in assay development, implementation and execution
  • Detailed familiarity with cochlear anatomy and physiology, in vivo and/or in vitro models of inner ear function, inner ear imaging techniques, inner ear histopathology, electrophysiology
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear