Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

If you want breakthrough science with tremendous growth opportunity, great colleagues and a stimulating work environment where you can make a difference in the lives of people with hearing disorders, we invite you to explore Decibel Therapeutics’ career opportunities.

To be considered for a position at Decibel Therapeutics, please submit your CV with the title of the position in the subject line to careers@decibeltx.com.

Equal Opportunity Employer M/F/D/V

Position Overview and Responsibilities:

The Director, Program Leadership & Management reports to the EVP, Corporate Development, and is responsible for significant Decibel research collaborations, and preclinical and early stage clinical programs.

The ideal candidate will have significant early stage drug development experience and alliance management experience, and will lead cross-functional pre-clinical and clinical stage program teams to define the optimal development strategy and to drive operational advancement of the program. The candidate will play a key role in day-to-day operations and long-range planning, and will represent the program teams in management settings and represent Decibel to collaboration partners.

Alliance management

  • For major research collaborations and partnered programs, serve as alliance manager to ensure strategic and operational alignment within the collaboration
  • Work with new and existing team members and partners to enable both parties to realize the full potential of each alliance
  • Ensure proactive and effective communication and governance. Coordinate across both organizations to meet both the letter and the spirit of the alliance governance provisions. Understand the partner’s internal people, roles, and decision-making processes to proactively engage with them to make decisions, as well as to know how and when to best engage when unexpected events emerge.
  • Develop and maintain a comprehensive knowledge of each contract as well as any associated or related contracts. Ensure we are adhering to our obligations and that our partner is adhering to theirs, including resourcing, finances, timelines, reports and information-sharing, disclosures, and decision-making. Collaborate closely with Finance and Legal.
  • While keeping a close eye on the contractual commitments and boundaries, maintain a wider perspective and continually consider the principles, spirit, and long-term goals of the alliance to ensure we are always driving towards those objectives.
  • Identify issues and opportunities that are “extra-contractual” and work both internally and with the partner to construct a path forward to address or capitalize on each.
  • Foster alliance management understanding and skills across the organization.
  • Work closely with and support cross-functional teams to prepare for interactions with our partners.
  • Manage partner meetings and document the key discussion points and decisions taken at those meetings.

Early stage program leadership

For programs from initiation of IND-enabling activities through POC

  • Foster a team culture that encourages each member to challenge ideas and openly raise issues.
  • Leverage input from all critical functions to create integrated strategic development plans that define goals, milestones, critical path, timeline, risks, assumptions, alternative scenarios, and budget.
  • Driving decision making in governance settings, to execute on the development strategy
  • Mobilize and align the organization, and inspire commitment amongst the program team
  • Effectively communicate with and present or report to senior leadership and to the company on program strategy, operational plans and progress.

Early stage program management

For programs from initiation of IND-enabling activities through POC

  • Develop effective program management capabilities at Decibel, appropriate to our current stage of growth.
  • Establish and monitor project goals as well as go/no go criteria for all key decision points
  • Proactively identify and prioritize program risks, and develop and monitor risk mitigation plans

The successful candidate has:

  • 10+ years in drug development
  • 5+ years in program and/or alliance management
  • Significant depth in early program leadership (IND-enabling through POC); additional late stage clinical development experience desirable
  • An instinct, honed through experience, for sensing problems early that could derail ultimate regulatory approval or commercial relevance, combined with a capacity for solution-based, creative thinking and “can do” / “do what it takes” attitude
  • Strong understanding of inter-dependencies between disciplines in drug development; demonstrated knowledge of several allied disciplines, such as DMPK, pharmacology, toxicology, regulatory, clinical development, CMC.
  • Experience as the alliance manager at the smaller company in a significant corporate alliance is desirable.
  • A passion for developing and delivering hearing therapeutics
  • Demonstrated ability to balance conflicting priorities across multiple disciplines and programs.
  • Strong interpersonal skills and the ability to motivate others, to direct activity from a position of informal influence, to negotiate conflict situations, and to forge consensus between competing points of view.
  • Bachelor’s Degree; Master’s preferred
  • Ability and willingness to travel 10-15%

Position Overview & Responsibilities:

Decibel Therapeutics is looking for a Research Associate/Scientist with experience in in vivo electrophysiology to be part of the pharmacology team working to test potential novel therapies for hearing loss. The primary responsibilities are to help develop and to execute studies requiring functional assays (auditory brainstem response; otoacoustic emissions) for quantitating hearing status/hearing loss in animal models. The individual in this position will have the opportunity to work closely with biology and drug delivery/PK teams, across multiple projects and indications.

The successful candidate will be highly motivated to work as part of a team in a fast-paced, dynamic environment. Additionally, the ideal candidate will be highly self-motivated and enthusiastic to join the wider Decibel team in working to understand the bases of hearing losses and to generate treatments that benefits patients, their families and communities.

Requirements

  • BS, MS or PhD in Neuroscience, Physiology, Pharmacology, Biology, or related fields
  • 0-2 years with PhD/ 2 years with MS of research experience in industry or academic laboratories
  • Hands-on experience with in vivo electrophysiology (field potentials, multi-unit, or single-unit), including data acquisition, analysis, and visualization
  • Excellent animal handling and experience with IP, IV, PO administration
  • Ability to develop and execute research studies, critically assess data quality and results, and effectively communicate results to the team
  • High level of interpersonal skills, including working/communicating with multiple teams
  • Ability to time-manage and work on multiple projects
  • Ability to work in a dynamic environment

Additional desirable experience

  • Developing animal models, especially animal models of hearing loss
  • Recording auditory brainstem response, otoacoustic emissions, or other auditory evoked responses
  • Surgery and dissection

Position Overview and Responsibilities:
As a Scientist, Hearing Biology you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vivo and/or in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • PhD in neurobiology, molecular and/or cell biology with 1 to 3+ year’s relevant experience or BA or MA with  to 3-6+ year’s relevant industry experience
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, surgical approaches for delivery to the inner ear, AAV gene delivery, dissection and histology of the adult inner ear, microscopy, and RNA/protein analysis
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in other hearing-related fields (e.g. at least one of tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing)
  • Strong problem-solving skills
  • Ability to be productive in a fast-paced, team-work, multi-task environment
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team
  • Outstanding interpersonal and communication skills

Knowledge, Skills, and Abilities:

  • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Prepare protocols and SOPs for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology/pharmacology group and cross functional project teams
  • Review the scientific literature to remain abreast of developments in relevant fields

Preference will be given to candidates who additionally have:

  • Expertise in in vitro (cell lines and explants) models relevant to the inner ear with proven track record in assay development, implementation and execution
  • Detailed familiarity with cochlear anatomy and physiology, in vivo and/or in vitro models of inner ear function, AAV delivery to the inner ear, inner ear imaging techniques, microdissection of the adult inner ear, inner ear histopathology, electrophysiology

Position Overview and Responsibilities:
As the Senior Scientist, you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Decibel. Your initial focus will be to develop, implement and execute appropriate in vivo and/or in vitro assays required for the advancement of both specific high priority projects as well as Decibel’s inner ear platform. As one of the key early hires for the company, you will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and grounded in realistic, corporate aligned goals.

Requirements:

  • PhD in pharmacology, neurobiology, molecular and/or cell biology with 3 to 5+ year’s relevant experience or BA or MA with 12 to 15+ year’s relevant industry experience
  • At least 5 years of experience working on early-stage and IND-enabling teams within the pharmaceutical industry
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, histology and RNA/protein expression techniques
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in other hearing-related fields (e.g. at least one of tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing)
  • Proven track record in new assay and high-through put assay development
  • Strong problem-solving skills
  • Ability to be productive in a fast-paced, team-work, multi-task environment
  • Ability to function equally well in self-starter mode as well as a member of a matrixed team
  • Outstanding interpersonal and communication skills

Knowledge, Skills, and Abilities:

  • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Prepare protocols and SOPs for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology/pharmacology group and cross functional project teams
  • Review the scientific literature to remain abreast of developments in relevant fields

Preference will be given to candidates who additionally have:

  • Expertise in in vitro (cell lines and explants) models relevant to the inner ear with proven track record in assay development, implementation and execution
  • Detailed familiarity with cochlear anatomy and physiology, in vivo and/or in vitro models of inner ear function, inner ear imaging techniques, inner ear histopathology, electrophysiology
  • Deep expertise in regenerative medicine strategies, preferably in the inner ear

The Position:
The Vice President of Biology will envision and lead the scientific team that will deliver high value targets for the company’s inner ear platform and therapeutic indications. You will have oversight for the development of the robust pipeline of molecular targets that ensures a steady stream therapeutics onwards. You will identify and maintain key external scientific relationships relevant to developing and maintaining the pipeline. By communicating accurately and regularly with team members, the Vice President will drive the strategy, progress, risks and risk mitigation plans for all Biology programs. As a key early hire for the company, a critical component of the job will be close collaboration with internal discovery teams and external investigators.

Requirements:

  • MD, PhD or MD PhD
  • Minimum of 15 years’ experience in industry, successfully leading teams towards drug discovery and/or 20 years’ experience in academia with an internationally acknowledged strong record of publications and mentoring
  • International reputation in the field of neurology or inner ear biology
  • Demonstrated leadership in a multi-discipline high performance team
  • Demonstrated ability to assess, prioritize, resource and shepherd programs forward
  • Outstanding interpersonal and communication skills

Preference will be given to candidates who additionally have:

  • Broad scientific expertise in the hearing field
  • Expertise in ototoxicity, growth factors, and/or cochlear implants
  • Outstanding oral and written presentation skills