Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

If you want breakthrough science with tremendous growth opportunity, great colleagues and a stimulating work environment where you can make a difference in the lives of people with hearing disorders, we invite you to explore Decibel Therapeutics’ career opportunities.

To be considered for a position at Decibel Therapeutics, please submit your CV with the title of the position in the subject line to careers@decibeltx.com.

Equal Opportunity Employer M/F/D/V

Job Description:

Decibel is seeking an IT professional to lead the design, implementation and growth of our core IT platform.  This individual with manage infrastructure and resources to meet organizational needs and will be responsible for working cross-functionally with all departments to identify long-term, scalable, practical solutions for research and operations as the organization grows.   He/she will be expected to establish close partnerships with colleagues from multiple disciplines to translate business needs into a state-of-the-art information technology platform.

Responsibilities:

Leadership

  • Provide strong leadership and business acumen, as well as technical development and relationship-building capabilities to inspire the organization around common goals, vision and values for IT.
  • Define and implement an infrastructure and core services architecture to meet our company-wide strategy for data storage, compute/analytics, and information management.
  • Serve as champion for data and technology governance, systems quality and vendor relationships across the company.
  • Grow the breadth and depth of department expertise to meet short and long-term corporate objectives.

Information Technology

  • Oversee contingency planning and IT security and compliance by establishing controls and processes in support of data security, PHI, SOX and other relevant regulatory requirements.
  • Manage vendors, consultants and overall budget for IT.
  • Lead the planning and cost estimation of IT initiatives and core services.
  • Regularly and effectively communicate with key project stakeholders, keeping them advised of project progress and generally making IT activities transparent to stakeholders.
  • Set strategy for IT infrastructure and service capabilities for current and future organizational needs.
  • Maintain ongoing knowledge of industry trends and ability to utilize that knowledge to determine the most efficient ways to meet the company’s evolving business needs.
  • Communicate strategy to scientific, operations and senior management to ensure alignment.
  • Organize and develop training program for enterprise applications and systems to ensure effective and consistent use and compliance with security and regulatory requirements.
  • Measure availability, performance, capacity, and utilization of IT and core application services.
  • Take ownership of security and IT related compliance for the company.
  • Collaborate with others to lead the definition, design, implementation, and management of IT systems and processes that support and integrate the overall scientific and business technology platform.
  • Grow and effectively maintain cloud first infrastructure and service environment to enable agility while ensuring secure operations and efficient utilization of resources.

Minimum requirements:

  • Degree in computer science or related technical discipline plus 5-7 years of relevant experience managing IT infrastructure and services with at least 2-3 years in a biotech environment.
  • Ability to identify impediments to complex business and technical issues and provide timely and cost-effective solutions.
  • Solid technical and domain knowledge to ensure technology roadmap and execution plan for infrastructure, systems, and services are an appropriate fit to overall business needs.
  • Experience with evaluating, implementing and managing infrastructure (storage/compute/networking), enterprise systems, and core services.
  • Prior experience in successfully implementing, utilizing and leveraging outsourcing strategies.
  • Ability to adapt to increasing scope and complexity of work brought on by growth/change and helps others manage through change
  • Strong written, oral and public speaking communication skills.
Position Overview

This position will have a mix of strategic, financial and operational responsibilities and will collaborate with a wide array of departments (Centers of Excellence or COEs) and Program Teams. The position will be responsible for budgets (Financial Investment Plans), reforecasts, long-range plans, net present value estimates, variance analysis and other ad-hoc reports.  This roll will be a key part of the Finance team and will work closely with Corporate Development.

Responsibilities

  • Help lead the long-range planning, annual Financial Investment Plan and quarterly reforecasting efforts
  • Provide financial planning, analysis and support to drive decisions
  • Partner with the COEs/program teams to manage and forecast spend (become part of those program teams)
  • Develop and apply an understanding of spending trends and tendencies to manage financial risk and identify opportunities
  • Manage/understand variances to plan for R&D spend on a monthly, quarterly and annual basis
  • Budget/report the allocation of FTE resources on a monthly basis
  • Assist with the presentation of monthly results to program leads/COE heads
  • Special projects, system implementation and ad-hoc analysis as needed
  • Cross train on other key functions within the Finance team

 

Requirements

  • Bachelor’s and/or Master’s degree in Economics/Accounting/Finance or similar discipline
  • Five+ years of finance experience in the biotechnology or pharmaceutical industry and/or strategic consulting discipline
  • Strong financial modeling and analytical skills; highly proficient in MS Excel
  • Ability to navigate and influence in a matrixed organizational structure; highly collaborative
  • Attention to detail, but able to see the big picture
  • Passion to understand the business

Additional Desirable Experience:

  • MBA strongly preferred
  • Experience with ERP systems (Oracle Fusion preferred)
  • Knowledge of control environment of a biotechnology company

 

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.

Position Overview

We are seeking a motivated, skilled, and articulate Medical Director, Clinical Development, to play a key role in the development, conduct, and analysis of clinical programs in the field of hearing, including drugs to protect, repair, and restore hearing. The position will report to the Chief Medical Officer and will involve intense collaboration with academic investigators/ scientific experts to develop outstanding clinical protocols and ensure optimal study conduct, including development of data collection and study reporting systems and adherence to GCP guidelines and other relevant health authority regulations.

Responsibilities

  • Responsible for developing and implementing the Development Strategy for assets assigned, including the design, conduct, and interpretation of data from Phase 1 and 1/2 studies, and pediatric studies as required to fulfill regulatory requirements.
  • Provide clinical development input to pre-clinical programs approaching IND-enabling tox.
  • Bring programs into the clinic.
  • Direct all aspects of activities relating to: preparation of protocols, clinical trials, data analyses, and written study reports, including being the medical monitor for clinical trials.
  • Develop strong network of clinical advisors to provide input on Decibel’s clinical development programs and to serve as investigators on studies.
  • Lead study teams to ensure that the clinical aspects of protocols are properly executed.
  • Interact with CRO and other vendor relationships.
  • Serve as primary interface with internal stakeholders as well as external thought leaders and regulatory authorities for assigned programs.
  • As business needs require, provide technical evaluation of business development activities for proof of concept stage hearing assets.

Requirements

  • At least 3 years in pharmaceutical industry with experience in leading clinical trials supporting registration and interaction with global regulatory authorities.
  • Professional credentials as a physician (MD).
  • Experience in audiology, otolaryngology, or neurology preferred.
  • Experience in running gene therapy trials is a plus.
  • Experience in leading and managing project teams and managing multiple projects concurrently.
  • Thorough knowledge of clinical trial approval processes, including a strong grasp of international guidelines and regulations (FDA, ICH, and GCP).

Additional Desirable Experience

  • Excellent oral and written communication skills as well as the ability to facilitate analysis and problem solving through the effective facilitation of group activities.
  • Strong organizational and time management skills, including the ability to function effectively in a team environment.
  • Demonstrated professionalism and adherence to high ethical standards.
  • Demonstrated ability to manage multiple priorities to achieve results and meet milestones in a “hands-on” fashion.

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law. All employment is decided on the basis of qualifications, merit, and business need.

The Senior/Principal Computational Scientist, reporting to the Director of Computational Biology, will work as part of cross-functional project teams to drive research focused on the elucidation of hearing biology and the discovery and development of therapeutics for hearing loss.  Responsibilities will include:

  • Help develop a robust platform for genomics-based target discovery, including single-cell RNAseq data, population genetic data, and genetic screen data.
  • Apply and/or develop data-mining techniques for target identification and validation.
  • Apply machine learning and statistical approaches to establish and benchmark predictive models of biological data.
  • Help guide design of gene therapies, including computational aspects of promoter and capsid optimization.
  • Enhance the scientific reputation of the company through publishing and/or or presenting technical papers to internal and external audiences, and/or contributing to patent applications.
  • Design and develop innovative, robust, analysis pipelines that can be applied in a research and clinical setting.
  • Develop and contribute to external collaborations and partnerships.

Requirements:

  • M.S./Ph.D. in bioinformatics, computational biology, genetics or a related discipline.
  • Strong understanding of cellular and molecular biology. Understanding of hearing biology is a plus.
  • Expertise in computational biology, genomics and other high throughput data platforms including scRNAseq. Aptitude to apply experimental methods to understand disease biology and drug discovery.
  • Proficiency in programming and computational analysis. Experience with R, Python and SQL are desirable.
  • Ability to apply and develop tools for integrative analysis and visualization of multi-dimensional datasets, integrating biochemical, cellular and genomic data using appropriate statistical methods to drive drug discovery projects.
  • Ability to work effectively with internal and external collaborators to funnel emerging genomics discoveries to guide internal programs and identify partners/consultants to complement internal bioinformatics efforts.
  • Other ideal areas of scientific expertise:
    • Fundamental statistics and machine learning applications to life sciences
    • Predictive modeling, benchmarking
    • Experience with mining public data sets
  • Technical proficiencies should include:
    • Linux in a grid or cloud environment.
    • One or more scripting and statistical languages
    • Distributed computing
  • Excellent written and verbal communication skills, particularly of complex information and concepts.

 

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.

 

Position Overview and Responsibilities:

Decibel is seeking a subject matter expert with strong leadership skills to drive Genomics and Systems Biology efforts supporting target identification and drug discovery.  This person will capitalize on Decibel’s existing single-cell RNAseq platform to deliver biologically meaningful results that impact Decibel’s programs.  Core responsibilities include:

  • Help lead a multidisciplinary team of biologists and computational biologists to design, conduct, and analyze genomics studies
  • Manage the Genomics and Systems Biology needs of Decibel’s scientific programs
  • Industrialize and improve existing single-cell RNAseq and RNAScope platforms
  • Enhance existing platform with new genomics tools that work with limited amounts of starting material, including but not limited to in situ sequencing, ATAC-Seq, ChIP-Seq, and proteomics
  • Help develop new genetic screening tools, including forward/reverse genetics in animal models and multiplex CRISPR-based approaches
  • Work with computational biologists to build new analysis pipelines for genomics datasets
  • Develop deep understanding of inner ear disease pathology at the molecular level
  • Make a significant contribution to the identification and validation of new targets in complex disease areas
  • Enhance the scientific reputation of the company through publishing and/or or presenting technical papers to internal and external audiences, and/or contributing to patent applications
  • Work with external contract research organizations to conduct studies in a timely manner
  • Identify and obtain relevant existing genomics datasets from external sources
  • Develop and contribute to external collaborations and partnerships

Requirements:

  • Ph.D. in genomics, systems biology, neurobiology, bioengineering, molecular and/or cell biology with 10+ year’s relevant experience
  • Hearing biology expertise preferred
  • Hands-on experience and deep working knowledge of both the laboratory and the computational component of ‘omics workflows
  • Strong understanding of genetic screening and CRISPR.  Hands-on experience preferred.
  • Proficiency in programming and computational analysis. Experience with R and Python preferred.
  • Prior experience with industrializing workflows and establishing SOPs.
  • Ability to work effectively with internal and external collaborators to funnel emerging genomics discoveries to guide internal programs and identify partners/consultants to complement internal bioinformatics efforts.

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.