Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair and restore hearing. By combining recent innovations in hearing science with leading diagnostic tools, biological insights, and therapeutic delivery techniques, Decibel is pioneering a comprehensive approach to define the underlying biological causes of these hearing disorders and is developing a pipeline of breakthrough drugs. We are passionate in our commitment to bring meaningful therapeutics to people with hearing disorders, to create a world in which the benefits and joys of hearing are available to all.

We are building the world’s leading team in hearing. Decibel is looking for extraordinary individuals to join our expanding group of energetic, enthusiastic and inspired professionals.

If you want breakthrough science with tremendous growth opportunity, great colleagues and a stimulating work environment where you can make a difference in the lives of people with hearing disorders, we invite you to explore Decibel Therapeutics’ career opportunities.

To be considered for a position at Decibel Therapeutics, please submit your CV with the title of the position in the subject line to careers@decibeltx.com.

Equal Opportunity Employer M/F/D/V

Position Overview & Responsibilities:

The Informatics Associate provides technical and business workflow analysis and end user support for scientific applications used in areas across Preclinical Research, Clinical Development and G&A functions to support the company daily operating needs and future growth.

In this role the successful candidate will communicate with scientific application users and leaders to understand their needs and challenges and requirements for software systems. The Informatics Associate will take direct action to respond to needs, troubleshoot problems, and facilitate productivity through utilization of application resources. Responsibilities also include developing business processes and workflows for data management systems, tracking, acquisition, and analysis of data based upon the needs of internal research customers. The role calls for a combination of scientific training and informatics expertise. A strong technical background in Life Science applications, coupled with exceptional customer service skills is needed.

  • Support end-user applications to help with application functionality, future configurations and troubleshoot basic problems; Learn internal systems to become the knowledge expert.
  • Develop scripts, workflows, and automation procedures for routine lab workflows
  • Handle escalated technical issues both with IT and Informatics related issues/requests for applications used within the company
  • Assist in managing interactions with support resources from software vendors or external help desk(s)
  • Collaborate with cross functional groups of experts in other parts of the IT organization as required
  • Assist with testing of new system deployments, UAT scripts, and documentation of systems or workflows.
  • Work closely with external MSP for HelpDesk items and resolution of higher priority issues pertaining to deployed applications
  • Conduct or organize systems/platform trainings for new applications or updates to platforms/applications
  • Conduct and/or coordinate system updates across the company.  Schedule/Deliver corporate applications trainings.

Requirements:

The qualified candidate will possess a track record of providing software implementation and support services in a life science or healthcare environment. Technical acumen, excellent written and verbal communication skills, and a demonstrated potential to continually grow into new responsibilities are needed. They must be self-motivated and able to work independently, but also recognize when to reach for assistance from other available resources to solve problems. Specific qualifications include:

  • BA/BS/MS in Computer Science, Engineering or related technical disciplines preferred
  • 3-7+ years of relevant professional experience in academic or biopharma research institution
  • Training in a relevant life science
  • Expert user experience with several scientific applications for biology, chemistry, or pharmacology such as LIMS, SDMS, Data Visualization, ELN’s and others.(Biovia, IDBS, ChemAxon, Dotmatics, related)
  • Familiarity with clinical systems such as EDC, eTMF, CTMS and others would be beneficial but not required
  • Familiarity with scientific software used for computation and visualization.
  • Ability to create automation scripts using shell scripting, Python, SQL, and related scripting and query languages, experience with tools such as Pipeline Pilot, Spotfire, Tableau is a plus
  • Experience supporting researchers and scientists in biotech/pharma, or equivalent academic research computing environment.
  • Exceptional analytical, problem-solving, and troubleshooting abilities.
  • Strong written and verbal communication skills.

 

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.

 

Decibel Therapeutics is looking for a highly motivated, responsible recent graduate who wants to enter industry to gain hands-on experience in drug discovery.  As part of our in vitro pharmacology team, the qualified candidate will execute experiments to characterize compounds and validate targets of interest.  Ability to design and execute experiments, analyze and interpret results, identify issues, troubleshoot and propose solutions is essential.  Experience in cell culture and in vitro/ex vivo assays is highly desired.

The candidate should be self-motivated, fast learner, flexible and enthusiastic in response to changing needs in a fast-paced and highly collaborative environment.  The candidate should also be capable of working on multiple projects, and able to execute under time constraints that meet project goals.

 Position Overview & Responsibilities

  • Being a member of the in vitro pharmacology team supporting discovery and target ID efforts
  • Provide cell, molecular and biochemical biology support for multiple projects
  • Develop and execute in vitro/ex vivo assays to characterize small molecule compounds and validate targets of interest
  • Design and execute experiments, analyze and interpret results, document detailed experimental procedures and enter results into electronic lab notebooks

Requirements

  • B.S. or M.S. degree in biology, biochemistry, molecular, cell biology or related fields.
  • Excellent teamwork, communication and interpersonal skills.
  • Ability to design and execute experiments, analyze and interpret results, identify issues, troubleshoot and propose solutions.
  • Self-motivated, fast learner, flexible and enthusiastic in response to changing needs in a fast-paced and highly collaborative environment.
  • Highly organized, detail-oriented, and able to follow protocols, document experimental procedures and results in a laboratory notebook.
  • Capable of working on multiple projects, and able to execute on timelines that meet corporate goals
  • Excellent written and oral communication, and computer skills

Additional Desirable Experience

  • Experience in cell culture and in vitro assays highly desired
  • Research experience in the hearing field
  • Working experience in vitro/ex vivo, cell based or biochemical assays
  • Working experience in qPCR, ELISA, immunohistochemistry methods and microscopy
  • Comfortable with animal handling
  • Experience with microdissection, primary cell isolation and culture

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.

 

Decibel Therapeutics is looking for a Scientist with experience in the auditory system to be part of the pharmacology team working to identify novel therapies for the treatment of hearing loss.

As a Scientist, you will be expected to work equally well as a self-starter and as a member of a matrixed team within Decibel. Your focus will be to develop and execute appropriate in vivo assays required for the advancement of specific high priority projects as well as Decibel’s inner ear platform. You will work in close collaboration with the management team and scientists to ensure that our pre-clinical programs and technology platform are based on solid scientific foundations, accurate feasibility assessments, and are grounded in realistic, corporate aligned goals.

In this position you will lead the design and execution of in vivo pharmacology studies to determine the efficacy profile of novel compounds and their potential to treat hearing loss, using a variety of assays. In addition, you will be responsible for data analysis and interpretation and formulating the path for advancement through Decibel’s discovery programs.

The individual in this position will have the opportunity to work closely with biology, drug delivery/PK and translational research teams, across multiple projects and indications.

The successful candidate will be highly motivated to work as part of a team in a fast-paced, dynamic environment. Additionally, the ideal candidate will be highly enthusiastic to join the wider Decibel team in working to understand the bases of hearing losses and to generate treatments that benefits patients, their families and communities.

Requirements

  • PhD in pharmacology, molecular and/or cell biology or neurobiology with 3 to 5+ years relevant experience or Bachelors or Master’s degree with 12 to 15+ year’s relevant industry experience
  • Hands-on experience with in vivo electrophysiology (field potentials, multi-unit, or single-unit), including data acquisition, analysis, and visualization
  • Hands-on experience in diverse, in vivo and in vitro experimental model systems, molecular and cell biology, cell signaling and RNA/protein expression techniques
  • Experience in designing and executing experimental strategies to validate and understand the mechanism of action for identified targets
  • Broad vocabulary that encompasses significant (publications and/or INDs) experience in hearing-related fields (e.g. at least one of: tinnitus, noise-induced hearing loss, ototoxicity, presbycusis, genetic disorders relevant to hearing) or other indications
  • Ability to develop and execute research studies, critically assess data quality and results, and effectively communicate results to the team
  • Strong problem-solving skills
  • High level of interpersonal skills, including working/communicating with multiple teams
  • Ability to time-manage and work on multiple projects
  • Ability to work in a dynamic environment

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.

 

The Senior Computational Scientist, reporting to the Director of Computational Biology, will work as part of cross-functional project teams to drive research focused on the elucidation of hearing biology and the discovery and development of therapeutics for hearing loss.  Responsibilities will include:

  • Help develop a robust platform for genomics-based target discovery, including single-cell RNAseq data, population genetic data, and genetic screen data.
  • Apply and/or develop data-mining techniques for target identification and validation.
  • Apply machine learning and statistical approaches to establish and benchmark predictive models of biological data.
  • Help guide design of gene therapies, including computational aspects of promoter and capsid optimization.
  • Enhance the scientific reputation of the company through publishing and/or or presenting technical papers to internal and external audiences, and/or contributing to patent applications.
  • Design and develop innovative, robust, analysis pipelines that can be applied in a research and clinical setting.
  • Develop and contribute to external collaborations and partnerships.

Requirements:

  • M.S./Ph.D. in bioinformatics, computational biology, genetics or a related discipline.
  • Strong understanding of cellular and molecular biology. Understanding of hearing biology is a plus.
  • Expertise in computational biology, genomics and other high throughput data platforms including scRNAseq. Aptitude to apply experimental methods to understand disease biology and drug discovery.
  • Proficiency in programming and computational analysis. Experience with R, Python and SQL are desirable.
  • Ability to apply and develop tools for integrative analysis and visualization of multi-dimensional datasets, integrating biochemical, cellular and genomic data using appropriate statistical methods to drive drug discovery projects.
  • Ability to work effectively with internal and external collaborators to funnel emerging genomics discoveries to guide internal programs and identify partners/consultants to complement internal bioinformatics efforts.
  • Other ideal areas of scientific expertise:
    • Fundamental statistics and machine learning applications to life sciences
    • Predictive modeling, benchmarking
    • Experience with mining public data sets
  • Technical proficiencies should include:
    • Linux in a grid or cloud environment.
    • One or more scripting and statistical languages
    • Distributed computing
  • Excellent written and verbal communication skills, particularly of complex information and concepts.

 

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.

 

Decibel is seeking a Human Genetics Scientist, reporting to the Director of Computational Biology, to help drive collection and analysis of data around the genetics of hearing function, hearing loss, and genetic deafness. Responsibilities will include:

  • Design, conduct, and analyze human genetics studies to help drive drug discovery and development.
    • Identify and develop relationships with appropriate external partners.
    • Develop sample collection and genotyping strategy.
    • Work with translational sciences group to develop cohort selection and phenotyping strategies.
    • Develop and implement computational analysis strategy with appropriate statistical rigor.
  • Help develop a robust platform for human genetics data storage and access.
  • Help guide genomics platform efforts at Decibel, including genetic screening, single-cell RNAseq, and other data types.
  • Apply and/or develop data-mining techniques for target identification.
  • Apply machine learning and statistical approaches to establish and benchmark predictive models of disease.
  • Enhance the scientific reputation of the company through publishing and/or or presenting technical papers to internal and external audiences, and/or contributing to patent applications.
  • Design and develop innovative, robust analysis pipelines that can be applied in a research and clinical setting.
  • Develop and contribute to external collaborations and partnerships.

Requirements:

  • M.S./Ph.D. in bioinformatics, computational biology, genetics or a related discipline.
  • Strong understanding of statistical and population genetics. Understanding of hearing biology is a plus.
  • Experience in human genetic analysis and its application to practical problems.
  • Proficiency in programming and computational analysis. Experience with R, Python and SQL are desirable.
  • Ability to apply and develop tools for integrative analysis and visualization of multi-dimensional datasets, integrating biochemical, cellular and genomic data using appropriate statistical methods to drive drug discovery projects.
  • Ability to work effectively with internal and external collaborators to funnel emerging genomics discoveries to guide internal programs and identify partners/consultants to complement internal bioinformatics efforts.
  • Other ideal areas of scientific expertise:
    • Fundamental statistics and machine learning applications to life sciences
    • Predictive modeling, benchmarking
    • Experience with mining public data sets
  • Technical proficiencies should include:
    • Linux in a grid or cloud environment.
    • One or more scripting and statistical languages
    • Distributed computing
  • Excellent written and verbal communication skills, particularly of complex information and concepts.

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.

 

Position Overview & Responsibilities

The Senior/Staff Accountant will be responsible for compiling and analyzing financial information, managing day to day accounts payable transactions, processing and recording payroll, recording monthly general ledger entries, reconciling general ledger accounts and preparing monthly analysis. The Senior/Staff Accountant will be responsible for maintaining and developing strong accounting processes and control to ensure key accounts are reconciled in accordance with GAAP and transactions are processed and recorded in a timely fashion.  In addition, they will assist other members of the finance staff on monthly reporting and forecasting activities.

Requirements

  • Assist in managing the accounting and reporting function consisting of the monthly closing process, general ledger, and cash disbursements
  • Prepare and manage monthly reconciliations
  • Be a key member of the monthly reporting process, ensuring deadlines are met
  • Assist in leading the coordination and support of the independent auditors
  • Assist with the preparation of financial statements
  • Assist in managing all aspects of Accounts Payable, including working with our third party procurement vendor
  • Work closely with budget owners to ensure invoices are recorded accurately to facilitate meaningful budget to actual financial reporting
  • Timely processing of payroll and benefit management
  • Support and adhere to current internal control policies and procedures and help to identify areas where improvements can be made as the company grows and looks to enhance the control structure
  • Work with other members of the department as well as IT to continue to roll out new features of the ERP system
  • Work with Department members to streamline and find efficiencies in the month end process as well as other areas of accounting
  • Act as liaison between Accounting and other departments as required. Answer finance related inquiries from both internal and external sources
  • Provide accounting support for special projects and ad-hoc reporting and analysis as necessary
  • Other duties as assigned
  • BS Accounting

Additional Desirable Experience:

  • Operational experience with accounting and ERP systems
  • Life Science and or start up industry experience a plus
  • Strong knowledge on the application of US GAAP required
  • 3 years in Finance/Accounting with general ledger/month end close experience
  • Proficient in Excel.
  • Proven analytical and organizational skill
  • Able to work well independently
  • In-depth knowledge of accounting policies, internal controls and processes a plus.
  • CPA a plus but not required

 

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.

 

Decibel Therapeutics is looking for an experienced pharmacologist/biologist that will take a hands-on role as part of a team studying protection and repair of inner ear function.  The qualified candidate will execute experiments to discover new treatments for hearing loss.  The candidate should be able to work under minimal supervision, be team-oriented and collaborative. The candidate should be adept at troubleshooting.

 Position Overview & Responsibilities

In this position, the candidate will

  • Deliver compounds to the inner ear using surgical techniques that will allow to inject compounds in the labyrinth or in the bulla of small rodents of different ages.
  • Collect perilymph, CSF and plasma samples from small rodents.
  • Collect inner ear tissue samples for histological and/or molecular analysis and profiling.
  • Perform ABR and DPOAEs measurements in small rodents.
  • Conduct whole body perfusion and tissue collection for histological analysis.
  • Dissect the cochlea and process the tissue for histological analysis.
  • Analyze data, identify next steps, and communicate findings to the team.
  • Interact with various project teams to share and distribute information.
  • Work will be done as part of a team, regularly collaborating on tasks and communicating results.

Requirements

  • Experience with small animal surgery,  micro-dissection, survival surgery, and delivery to the inner ear are essential.
  • Candidate should also have experience in tissue handling, immunohistochemistry, histology, microscopy and in vivo dosing.
  • Experience with physiological recordings (ABR and DPOAEs) and basic statistics is an advantage.
  • Experience with in vivo models of hearing loss and a strong background in neuroscience will be an advantage.
  • BS and/or MS in Biology or related discipline required
  • PhD preferred
  • 5 years of lab experience in an academic or industrial setting
  • Independent and self-motivated.
  • Excellent written and oral communication skills

 

Decibel Therapeutics, Inc. is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce.  We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.  All employment is decided on the basis of qualifications, merit and business need.